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I would like to share my intitial impressions regarding tyrosol and
lignins. I finally got a chance to try a couple of products
containing these substances, and I was able to do a little checking,
including some blood pressure measurements. I am borderline
prehypertensive for various reasons, many of which are harmless, but I
like to keep an eye on it. It should be noted that these
impressions are preliminary, empirical, and anecdotal.
Lignins are a highly varied and often complex molecular species, so that it should always
be inquired as to what type of lignans are being referred to. I
am convinced that lignan molecules can be expected to be at the
frontier of longevity medicine. It is no surprise that there is
much excitement around these compounds, which have good free radical
quenching capabilities, and similar structures to other polyphenolic
compounds, which have been demonstrated to have enormously healthful
benefits.
Tyrosol is another molecule which shares in the same interesting
properties as lignans in the general sense, and in fact, many lignans
are based on tyrosol. These include the lignins in flax and
olive. Tyrosol has been demonstrated to have similar beneficial
qualities, but it is also deserving of certain caveats, as are the
tyrosol lignan class in general.
Tyrosol and tyrosol lignans are included in certain nasal and throat
spray preparations, and it is not surprising that they exhibit a
decongestant-like property, due to their similar structure to adenergic
molecules, such as norepinephrine. In fact, tyrosol has been
demonstrated to have antiarrhythmic effects, which could be beneficial
for some people. This is consistent with alpha-1 adenergic
activation, and explains the decongestant effect as well.
At this juncture, I would like to remind that these are preliminary
findings, and people should search out the matter in the literature for
themselves. My research is indicating at this time that alpha-1
activation is not beneficial from a longevity perspective, and is
likely to cause harm to people with rapid heartbeat or high blood
pressure. One reason for this is the resulting Akt activation,
which you can look up for yourself. I try to avoid alpha-1
activation, which is a stress
response. For this reason, I have until now tried to avoid
decongestant medicines, which are typically alpha-1 adenergics.
Tyrosol shares its molecular properties with norepinephrin, the body's
native alpha-1 receptor ligand, and as such it can be expected that
there are ameliorating factors which offset the problems. Although, alpha-1
activation may lead to runaway calcium cascades, tyrosine kinase
activation, and an increase in inflammatory factors, these effects
which are often adverse are offset by the phenolic structure of the
molecule, which may tend to scavange the resulting free radicals and
produce some of the other benefits that are associated with
polyphenols, like resveratrol.
My advice at this time is to use discretion and moderation when
supplementing with tyrosol and tyrosol lignins. Consider the
state of your health. Personally, with borderline
prehypertension, I will tend to use less than some other people. For
example, I will use the topical and intranasal preparations only as needed.
I have the flax oil with lignan fraction preparation from NSI, and I
think that
it could be beneficial, but due to these concerns, I will limit myself
to an
occasional 1/2 teaspoon. I like it in my yogurt fruit
smoothie, and it tastes better than olive oil in the juice. Much
more could obviously be said about olive oils. Anyway, for people
with low blood pressure and/or adverse
congestion and swelling in the nasal epithelium, the effects may be
more beneficial.
Adenergics are frequently a part of body building regimens, and I would
advice caution. There are beta-adenergic agonists, which are
probably more on target and effective than the alpha-1 agonists.
Moreover, they can be expected to be more heathful in the general sense
as well.
I am afraid that I am always eager to try the hottest new supplement,
in order to expand my longevity program, and as a result, I do not
always proceed with scientific rigor. I find myself backpedalling
from time to time, which is why I put the caveats on this piece.
I must confess that the observed effects could be due to a change in my
vitamin E regimen, but I find that unlikely.
For the future, I think that tannins are in a similar preliminary state
as lignins. There are huge potential benefits, but an equal
degree of concerns. I hope that this information helps someone, and I will post updates as I learn more.
Incidentally, for those concerned about high blood pressure, you might
want to have a look at forskolin. It is available in herbal
extract form from NSI. I recommend a strict regimen when
using forskolin, in order to avoid the rollercoaster effect. It
would probably be wise to consult with a healthcare professional about
it. I will probably have more to say about this later, as it is
related to this story above.
Finally, I would like to boost another new idea. I think
that phenolics which are not alpha-1 adenergic would be a better
addition to an intranasal spray. It would not give users that
familiar punch, but it would be more benefical in the long run.
There are many naturally occuring flavonoids, which are known to have
beneficial antimicrobal activity, and it should not be difficult to
find the best one, perhaps among the citrus variety. In a
suspension with a little citric acid to lower the pH and aid
absorption, it could be quite beneficial and effective, without the
alpha-1 body load... BTW, for the throat spray too.
Regards,
proclus
http://www.gnu-darwin.org/
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